Artesunate

Artesunate versus Chloroquine Infection

Fake artesunate in southeast Asia.

Artesunate is a key antimalarial drug in the treatment of multidrug-resistant Plasmodium falciparum malaria in southeast Asia. We investigated the distribution of counterfeit artesunate tablets by use of the validated, simple, and inexpensive Fast Red TR dye technique. We also aimed to identify distinguishing characteristics of the fake drugs. Of 104 shop-bought "artesunate" samples from Cambod...

Severe malaria, artesunate and haemolysis.

on two occasions, and the dose was adjusted accordingly a few times. He presented 2 weeks later with worsening symptoms of the right knee, including redness, swelling and pain. He was switched to 10 mg/kg telavancin intravenously every 24 h and rifampicin was continued. The MIC of telavancin was 0.25 mg/L. During the 6 week therapy with telavancin, the patient showed rapid improvement of sympto...

Population Pharmacokinetics of Artesunate and Dihydroartemisinin following Intra-Rectal Dosing of Artesunate in Malaria Patients

BACKGROUND Intra-rectal artesunate has been developed as a potentially life-saving treatment of severe malaria in rural village settings where administration of parenteral antimalarial drugs is not possible. We studied the population pharmacokinetics of intra-rectal artesunate and the relationship with parasitological responses in patients with moderately severe falciparum malaria. METHODS AN...

Activities of amodiaquine, artesunate, and artesunate-amodiaquine against asexual- and -sexual stage parasites in falciparum malaria in children Running title: antimalarial activities of artesunate and amodiaquine

Correspondence A. Sowunmi Department of Clinical Pharmacology University College Hospital Ibadan, Nigeria E-mail: [email protected] Fax: +234-2-2411843 Tel: 234-2 2412101 AC CE PT ED Copyright © 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.00077-07 AAC Accepts, published online ahead of p...